Acute pain following surgery known as the issue that most patients suوٴer from it; but chronic pain aіer surgery is a problem that has needed a little more attention. Depending on the type of surgery, 10% to 68% of surgical patients may be suوٴerLng from chronic pain that 2% to 10% of them suوٴer from severe pain. Нere is no exact definLtLon of chronic pain aіer surgery, and also dLوٴerences in diagnostic procedures and questionnaires used for evaluation of pain aіer surgery, may explain the dLوٴerences in prevalence rate in various studies. Currently it is accepted that duration of pain aіer surgery should be lasting at least two months aіer the operation time to make a trustworthy diagnosis. Risk factors of chronic pain aіer surgery divided into three periods: before surgery, during surgery and aіer surgery.

Pathophysiological processes that occur aÑ–er tissue damage indicate that acute pain may become persistent. ,nflammatLon at the site of tissue damage creates a barrage of aوٴerent nociceptors activity that causes peripheral and central nervous system sensitization and creates functional changes in the peripheral nerves, spinal cord, higher routes pain center and the sympathetic nervous system. It seems that specLfic receptor sites such as N-methyl-D-aspartate receptor is particularly important in chronic pain following acute injury and descending pathways pain control also probably the decisive factor in chronic pain. In another systematic review it has been shown that administration of Gabapentin consumption before surgery cause more reduced pain aÑ–er surgery compared to the control group and also may decrease the dose of opioids and side eوٴects. Chronic pain aÑ–er surgery oÑ–en has a neuropathic component. Even in the early stages, it can be seen as a neuropathic pain aÑ–er surgery. Нerefore drugs for treatment of chronic neuropathic pain are used as the adjuvant drug for pain ante surgery increasingly.

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